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Evaluation of the In Vivo and In Vitro Effects of Fructose on Respiratory Chain Complexes in Tissues of Young Rats
المؤلفون المشاركون
Streck, Emilio Luiz
Ferreira, Gustavo Costa
Scaini, Gisele
Macongonde, Ernesto António
Vilela, Thais Ceresér
Ferreira, Bruna Klippel
Costa, Naithan Ludian Fernandes
de Oliveira, Marcos Roberto
Avila, Silvio
Gonçalves, Cinara Ludvig
Schuck, Patrícia Fernanda
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-06
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Hereditary fructose intolerance (HFI) is an autosomal-recessive disorder characterized by fructose and fructose-1-phosphate accumulation in tissues and biological fluids of patients.
This disease results from a deficiency of aldolase B, which metabolizes fructose in the liver, kidney, and small intestine.
We here investigated the effect of acute fructose administration on the activities of mitochondrial respiratory chain complexes, succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) in cerebral cortex, liver, kidney, and skeletal muscle of male 30-day-old Wistar rats.
The rats received subcutaneous injection of sodium chloride (0.9%; control group) or fructose solution (5 μmol/g; treated group).
One hour later, the animals were euthanized and the cerebral cortex, liver, kidney, and skeletal muscle were isolated and homogenized for the investigations.
Acute fructose administration increased complex I-III activity in liver.
On the other hand, decreased complexes II and II-III activities in skeletal muscle and MDH in kidney were found.
Interestingly, none of these parameters were affected in vitro.
Our present data indicate that fructose administration elicits impairment of mitochondrial energy metabolism, which may contribute to the pathogenesis of the HFI patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Macongonde, Ernesto António& Vilela, Thais Ceresér& Scaini, Gisele& Gonçalves, Cinara Ludvig& Ferreira, Bruna Klippel& Costa, Naithan Ludian Fernandes…[et al.]. 2015. Evaluation of the In Vivo and In Vitro Effects of Fructose on Respiratory Chain Complexes in Tissues of Young Rats. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060903
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Macongonde, Ernesto António…[et al.]. Evaluation of the In Vivo and In Vitro Effects of Fructose on Respiratory Chain Complexes in Tissues of Young Rats. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1060903
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Macongonde, Ernesto António& Vilela, Thais Ceresér& Scaini, Gisele& Gonçalves, Cinara Ludvig& Ferreira, Bruna Klippel& Costa, Naithan Ludian Fernandes…[et al.]. Evaluation of the In Vivo and In Vitro Effects of Fructose on Respiratory Chain Complexes in Tissues of Young Rats. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060903
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060903
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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