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Evaluation of the In Vivo and In Vitro Effects of Fructose on Respiratory Chain Complexes in Tissues of Young Rats
Joint Authors
Streck, Emilio Luiz
Ferreira, Gustavo Costa
Scaini, Gisele
Macongonde, Ernesto António
Vilela, Thais Ceresér
Ferreira, Bruna Klippel
Costa, Naithan Ludian Fernandes
de Oliveira, Marcos Roberto
Avila, Silvio
Gonçalves, Cinara Ludvig
Schuck, Patrícia Fernanda
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hereditary fructose intolerance (HFI) is an autosomal-recessive disorder characterized by fructose and fructose-1-phosphate accumulation in tissues and biological fluids of patients.
This disease results from a deficiency of aldolase B, which metabolizes fructose in the liver, kidney, and small intestine.
We here investigated the effect of acute fructose administration on the activities of mitochondrial respiratory chain complexes, succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) in cerebral cortex, liver, kidney, and skeletal muscle of male 30-day-old Wistar rats.
The rats received subcutaneous injection of sodium chloride (0.9%; control group) or fructose solution (5 μmol/g; treated group).
One hour later, the animals were euthanized and the cerebral cortex, liver, kidney, and skeletal muscle were isolated and homogenized for the investigations.
Acute fructose administration increased complex I-III activity in liver.
On the other hand, decreased complexes II and II-III activities in skeletal muscle and MDH in kidney were found.
Interestingly, none of these parameters were affected in vitro.
Our present data indicate that fructose administration elicits impairment of mitochondrial energy metabolism, which may contribute to the pathogenesis of the HFI patients.
American Psychological Association (APA)
Macongonde, Ernesto António& Vilela, Thais Ceresér& Scaini, Gisele& Gonçalves, Cinara Ludvig& Ferreira, Bruna Klippel& Costa, Naithan Ludian Fernandes…[et al.]. 2015. Evaluation of the In Vivo and In Vitro Effects of Fructose on Respiratory Chain Complexes in Tissues of Young Rats. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060903
Modern Language Association (MLA)
Macongonde, Ernesto António…[et al.]. Evaluation of the In Vivo and In Vitro Effects of Fructose on Respiratory Chain Complexes in Tissues of Young Rats. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1060903
American Medical Association (AMA)
Macongonde, Ernesto António& Vilela, Thais Ceresér& Scaini, Gisele& Gonçalves, Cinara Ludvig& Ferreira, Bruna Klippel& Costa, Naithan Ludian Fernandes…[et al.]. Evaluation of the In Vivo and In Vitro Effects of Fructose on Respiratory Chain Complexes in Tissues of Young Rats. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060903