CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls
المؤلفون المشاركون
Trebst, Corinna
Stangel, Martin
Skripuletz, Thomas
Schwenkenbecher, Philipp
Pul, Refik
Yildiz, Özlem
Morbiducci, Franco
Götz, Friedrich
Berding, Georg
Donnerstag, Frank
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
CSF abnormalities have been reported in CSF leakage syndrome.
However, the mechanism for these CSF changes is actually unknown and they may indicate impaired CSF flow or blood-CSF barrier.
Angiopoietin-2 (Ang-2), a protein which is expressed and released by endothelial cells, has been associated with increased vascular permeability.
In the assumption that CSF changes are due to an impaired blood-CSF barrier, we hypothesized that subjects with persistent CSF leakage may have increased CSF Ang-2 levels.
We enrolled 10 subjects with a clinically definite diagnosis of persisting CSF leakage syndrome and 10 control subjects.
In CSF analyses, CSF to serum albumin ratio (Qalb) was the most frequently increased parameter indicating a disturbed blood-CSF barrier function.
Comparison of the mean CSF Ang-2 levels, CSF to serum Ang-2 ratio (QAng-2), and QAng-2/Qalb between the control and CSF leakage patients did not show any significant difference.
We suggest that the increase of Qalb results from a low CSF flow.
Future studies with phase contrast-MRI in conjunction with CSF analyses before and after epidural blood patch treatment are required to address this question.
It would be of particular interest whether Qalb can be used as a marker for successful nontargeted epidural blood patch treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pul, Refik& Yildiz, Özlem& Morbiducci, Franco& Skripuletz, Thomas& Schwenkenbecher, Philipp& Stangel, Martin…[et al.]. 2015. CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060912
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pul, Refik…[et al.]. CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060912
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pul, Refik& Yildiz, Özlem& Morbiducci, Franco& Skripuletz, Thomas& Schwenkenbecher, Philipp& Stangel, Martin…[et al.]. CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060912
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060912
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر