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CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls
Joint Authors
Trebst, Corinna
Stangel, Martin
Skripuletz, Thomas
Schwenkenbecher, Philipp
Pul, Refik
Yildiz, Özlem
Morbiducci, Franco
Götz, Friedrich
Berding, Georg
Donnerstag, Frank
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CSF abnormalities have been reported in CSF leakage syndrome.
However, the mechanism for these CSF changes is actually unknown and they may indicate impaired CSF flow or blood-CSF barrier.
Angiopoietin-2 (Ang-2), a protein which is expressed and released by endothelial cells, has been associated with increased vascular permeability.
In the assumption that CSF changes are due to an impaired blood-CSF barrier, we hypothesized that subjects with persistent CSF leakage may have increased CSF Ang-2 levels.
We enrolled 10 subjects with a clinically definite diagnosis of persisting CSF leakage syndrome and 10 control subjects.
In CSF analyses, CSF to serum albumin ratio (Qalb) was the most frequently increased parameter indicating a disturbed blood-CSF barrier function.
Comparison of the mean CSF Ang-2 levels, CSF to serum Ang-2 ratio (QAng-2), and QAng-2/Qalb between the control and CSF leakage patients did not show any significant difference.
We suggest that the increase of Qalb results from a low CSF flow.
Future studies with phase contrast-MRI in conjunction with CSF analyses before and after epidural blood patch treatment are required to address this question.
It would be of particular interest whether Qalb can be used as a marker for successful nontargeted epidural blood patch treatment.
American Psychological Association (APA)
Pul, Refik& Yildiz, Özlem& Morbiducci, Franco& Skripuletz, Thomas& Schwenkenbecher, Philipp& Stangel, Martin…[et al.]. 2015. CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060912
Modern Language Association (MLA)
Pul, Refik…[et al.]. CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060912
American Medical Association (AMA)
Pul, Refik& Yildiz, Özlem& Morbiducci, Franco& Skripuletz, Thomas& Schwenkenbecher, Philipp& Stangel, Martin…[et al.]. CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060912