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Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer
المؤلفون المشاركون
Wang, Jianjun
Yao, Yongliang
Wu, Jianhong
Li, Guangxin
Wang, Zeyou
Chen, Rui
Pu, XiongYong
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
MicroRNA-21 was upexpressed in gastric cancer (GC) indicating that it is a potential diagnostic biomarker for GC.
In this study, 50 GC patients and 50 healthy controls were recruited.
miR-21 levels in serum and peripheral blood mononuclear cells (PBMCs) were quantified using quantitative real-time PCR.
CA199, and CEA were measured using electrochemiluminescence assay.
The sensitivity and specificity of circulating miR-21, CA199 and CEA in GC diagnosis, the correlation of circulating miR-21 to clinicopathological features, and the diagnostic value of miR-21 in different GC stages were determined.
The levels of miR-21 in both serum and PBMCs increased significantly in GC patients comparing to healthy controls; however, no correlation was observed between circulating miR-21 level and clinicopathological features.
The sensitivity and specificity of miR-21 in serum and PBMCs, and CA199 and CEA in GC diagnosis were 88.4%, 79.6%, 81.3%, 73.4%, 60.5%, 55.9%, and 68.6%, 59.3%, respectively.
The positive prediction rates of circulating miR-21 in GC stages I to IV were all around 90%, while those of CA199 and CEA were around or less than 50%.
Our data suggest circulating miR-21 (both in serum and in PBMCs) can serve as a good biomarker for GC and could be used in diagnosis of early (stage I) and late GC (stage IV).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Jianhong& Li, Guangxin& Wang, Zeyou& Yao, Yongliang& Chen, Rui& Pu, XiongYong…[et al.]. 2015. Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060944
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Jianhong…[et al.]. Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060944
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Jianhong& Li, Guangxin& Wang, Zeyou& Yao, Yongliang& Chen, Rui& Pu, XiongYong…[et al.]. Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060944
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060944
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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