Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer
المؤلفون المشاركون
Wang, Jianjun
Yao, Yongliang
Wu, Jianhong
Li, Guangxin
Wang, Zeyou
Chen, Rui
Pu, XiongYong
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
MicroRNA-21 was upexpressed in gastric cancer (GC) indicating that it is a potential diagnostic biomarker for GC.
In this study, 50 GC patients and 50 healthy controls were recruited.
miR-21 levels in serum and peripheral blood mononuclear cells (PBMCs) were quantified using quantitative real-time PCR.
CA199, and CEA were measured using electrochemiluminescence assay.
The sensitivity and specificity of circulating miR-21, CA199 and CEA in GC diagnosis, the correlation of circulating miR-21 to clinicopathological features, and the diagnostic value of miR-21 in different GC stages were determined.
The levels of miR-21 in both serum and PBMCs increased significantly in GC patients comparing to healthy controls; however, no correlation was observed between circulating miR-21 level and clinicopathological features.
The sensitivity and specificity of miR-21 in serum and PBMCs, and CA199 and CEA in GC diagnosis were 88.4%, 79.6%, 81.3%, 73.4%, 60.5%, 55.9%, and 68.6%, 59.3%, respectively.
The positive prediction rates of circulating miR-21 in GC stages I to IV were all around 90%, while those of CA199 and CEA were around or less than 50%.
Our data suggest circulating miR-21 (both in serum and in PBMCs) can serve as a good biomarker for GC and could be used in diagnosis of early (stage I) and late GC (stage IV).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Jianhong& Li, Guangxin& Wang, Zeyou& Yao, Yongliang& Chen, Rui& Pu, XiongYong…[et al.]. 2015. Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060944
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Jianhong…[et al.]. Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060944
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Jianhong& Li, Guangxin& Wang, Zeyou& Yao, Yongliang& Chen, Rui& Pu, XiongYong…[et al.]. Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060944
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060944
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر