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Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer
Joint Authors
Wang, Jianjun
Yao, Yongliang
Wu, Jianhong
Li, Guangxin
Wang, Zeyou
Chen, Rui
Pu, XiongYong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
MicroRNA-21 was upexpressed in gastric cancer (GC) indicating that it is a potential diagnostic biomarker for GC.
In this study, 50 GC patients and 50 healthy controls were recruited.
miR-21 levels in serum and peripheral blood mononuclear cells (PBMCs) were quantified using quantitative real-time PCR.
CA199, and CEA were measured using electrochemiluminescence assay.
The sensitivity and specificity of circulating miR-21, CA199 and CEA in GC diagnosis, the correlation of circulating miR-21 to clinicopathological features, and the diagnostic value of miR-21 in different GC stages were determined.
The levels of miR-21 in both serum and PBMCs increased significantly in GC patients comparing to healthy controls; however, no correlation was observed between circulating miR-21 level and clinicopathological features.
The sensitivity and specificity of miR-21 in serum and PBMCs, and CA199 and CEA in GC diagnosis were 88.4%, 79.6%, 81.3%, 73.4%, 60.5%, 55.9%, and 68.6%, 59.3%, respectively.
The positive prediction rates of circulating miR-21 in GC stages I to IV were all around 90%, while those of CA199 and CEA were around or less than 50%.
Our data suggest circulating miR-21 (both in serum and in PBMCs) can serve as a good biomarker for GC and could be used in diagnosis of early (stage I) and late GC (stage IV).
American Psychological Association (APA)
Wu, Jianhong& Li, Guangxin& Wang, Zeyou& Yao, Yongliang& Chen, Rui& Pu, XiongYong…[et al.]. 2015. Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060944
Modern Language Association (MLA)
Wu, Jianhong…[et al.]. Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060944
American Medical Association (AMA)
Wu, Jianhong& Li, Guangxin& Wang, Zeyou& Yao, Yongliang& Chen, Rui& Pu, XiongYong…[et al.]. Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060944