Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study
المؤلفون المشاركون
Buendia-Jimenez, Inmaculada
Richardot, Pascaline
Picard, Pascaline
Lepicard, Eve M.
De Meo, Michel
Talaska, Glenn
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The association between fluid intake and bladder cancer risk remains controversial.
Very little is known about to which extent the amount of water intake influences the action of excreting toxics upon the urinary system.
This proof of concept trial investigates the effect of water intake on mutagenesis in smokers, a high risk population for bladder cancer.
Methods.
Monocentric randomized controlled trial.
Inclusion Criteria.
Male subjects aged 2045–45 y/o, smokers, and small drinkers (24-hour urinary volume <1 L and osmolality >700 mOsmol/kg).
Outcomes.
4-ABP DNA adducts formation in exfoliated bladder cells in 24-hour urine collection and urinary mutagenicity in 24-hour urine.
Test Group.
Subjects consumed 1.5 L daily of the study product (EVIAN) on top of their usual water intake for 50 days.
Control Group.
Subjects continued their usual lifestyle habits.
Results.
65 subjects were randomized.
Mean age was 30 y/o and mean cigarettes per day were 20.
A slight decrease in adducts formation was observed between baseline and last visit but no statistically significant difference was demonstrated between the groups.
Urinary mutagenicity significantly decreased.
The study shows that increasing water intake decreases urinary mutagenicity.
It is not confirmed by urinary adducts formation.
Further research would be necessary.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Buendia-Jimenez, Inmaculada& Richardot, Pascaline& Picard, Pascaline& Lepicard, Eve M.& De Meo, Michel& Talaska, Glenn. 2015. Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Buendia-Jimenez, Inmaculada…[et al.]. Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Buendia-Jimenez, Inmaculada& Richardot, Pascaline& Picard, Pascaline& Lepicard, Eve M.& De Meo, Michel& Talaska, Glenn. Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر