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Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study
Joint Authors
Buendia-Jimenez, Inmaculada
Richardot, Pascaline
Picard, Pascaline
Lepicard, Eve M.
De Meo, Michel
Talaska, Glenn
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The association between fluid intake and bladder cancer risk remains controversial.
Very little is known about to which extent the amount of water intake influences the action of excreting toxics upon the urinary system.
This proof of concept trial investigates the effect of water intake on mutagenesis in smokers, a high risk population for bladder cancer.
Methods.
Monocentric randomized controlled trial.
Inclusion Criteria.
Male subjects aged 2045–45 y/o, smokers, and small drinkers (24-hour urinary volume <1 L and osmolality >700 mOsmol/kg).
Outcomes.
4-ABP DNA adducts formation in exfoliated bladder cells in 24-hour urine collection and urinary mutagenicity in 24-hour urine.
Test Group.
Subjects consumed 1.5 L daily of the study product (EVIAN) on top of their usual water intake for 50 days.
Control Group.
Subjects continued their usual lifestyle habits.
Results.
65 subjects were randomized.
Mean age was 30 y/o and mean cigarettes per day were 20.
A slight decrease in adducts formation was observed between baseline and last visit but no statistically significant difference was demonstrated between the groups.
Urinary mutagenicity significantly decreased.
The study shows that increasing water intake decreases urinary mutagenicity.
It is not confirmed by urinary adducts formation.
Further research would be necessary.
American Psychological Association (APA)
Buendia-Jimenez, Inmaculada& Richardot, Pascaline& Picard, Pascaline& Lepicard, Eve M.& De Meo, Michel& Talaska, Glenn. 2015. Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060958
Modern Language Association (MLA)
Buendia-Jimenez, Inmaculada…[et al.]. Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060958
American Medical Association (AMA)
Buendia-Jimenez, Inmaculada& Richardot, Pascaline& Picard, Pascaline& Lepicard, Eve M.& De Meo, Michel& Talaska, Glenn. Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060958