Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker

الملخص EN

Objective.

To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN).

Methods.

sNRP-1 was measured in 64 preoperative patients and 20 controls.

NRP-1 protein in cervical tissue was detected in 56 patients and 20 controls.

Results.

Both sNRP-1 and NRP-1 proteins were correlated with stage.

sNRP-1 presented a high diagnostic ability of cervical cancer and CIN, with a sensitivity of 70.97% and a specificity of 73.68%.

Conclusions.

sNRP-1 in circulating can serve as a possible valuable diagnostic biomarker for cervical cancer and CIN.