NT-proBNP as Early Marker of Subclinical Late Cardiotoxicity after Doxorubicin Therapy and Mediastinal Irradiation in Childhood Cancer Survivors
المؤلفون المشاركون
Zidan, Amal
El-sheikh, Amera
Saleh, Safaa H.
Shahbah, Doaa A.
Sherbiny, Hanan S.
Ahmad, Heba
Kamal, Naglaa M.
Sherief, Laila M.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Childhood cancer survivors treated with anthracyclines and mediastinal irradiation are at risk for late onset cardiotoxicity.
Aims of the Study.
To assess the role of N-terminal pro-brain natriuretic peptide (NT-proBNP) and tissue Doppler imaging (TDI) as early predictors of late onset cardiotoxicity in asymptomatic survivors of childhood cancer treated with doxorubicin with or without mediastinal irradiation.
Methods.
A cross-sectional study on 58 asymptomatic survivors of childhood cancer who received doxorubicin in their treatment protocols and 32 asymptomatic Hodgkin’s lymphoma survivors who received anthracycline and mediastinal irradiation.
Levels of NT-proBNP, TDI, and conventional echocardiography were determined.
Results.
Thirty percent of survivors had abnormal NT-proBNP levels.
It was significantly related to age at diagnosis, duration of follow-up, and cumulative dose of doxorubicin.
TDI detected myocardial affection in 20% more than conventional echocardiography.
Furthermore, abnormalities in TDI and NT-pro-BNP levels were more common in Hodgkin lymphoma survivors receiving both chemotherapy and radiotherapy.
Conclusions.
TDI could detect early cardiac dysfunction even in those with normal conventional echocardiography.
Measurement of NT-proBNP represents an interesting strategy for detecting subclinical cardiotoxicity.
We recommend prospective and multicenter studies to validate the role of NT-proBNP as an early marker for late onset doxorubicin-induced cardiotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zidan, Amal& Sherief, Laila M.& El-sheikh, Amera& Saleh, Safaa H.& Shahbah, Doaa A.& Kamal, Naglaa M.…[et al.]. 2015. NT-proBNP as Early Marker of Subclinical Late Cardiotoxicity after Doxorubicin Therapy and Mediastinal Irradiation in Childhood Cancer Survivors. Disease Markers،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060964
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zidan, Amal…[et al.]. NT-proBNP as Early Marker of Subclinical Late Cardiotoxicity after Doxorubicin Therapy and Mediastinal Irradiation in Childhood Cancer Survivors. Disease Markers No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1060964
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zidan, Amal& Sherief, Laila M.& El-sheikh, Amera& Saleh, Safaa H.& Shahbah, Doaa A.& Kamal, Naglaa M.…[et al.]. NT-proBNP as Early Marker of Subclinical Late Cardiotoxicity after Doxorubicin Therapy and Mediastinal Irradiation in Childhood Cancer Survivors. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060964
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060964
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر