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NT-proBNP as Early Marker of Subclinical Late Cardiotoxicity after Doxorubicin Therapy and Mediastinal Irradiation in Childhood Cancer Survivors
Joint Authors
Zidan, Amal
El-sheikh, Amera
Saleh, Safaa H.
Shahbah, Doaa A.
Sherbiny, Hanan S.
Ahmad, Heba
Kamal, Naglaa M.
Sherief, Laila M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Childhood cancer survivors treated with anthracyclines and mediastinal irradiation are at risk for late onset cardiotoxicity.
Aims of the Study.
To assess the role of N-terminal pro-brain natriuretic peptide (NT-proBNP) and tissue Doppler imaging (TDI) as early predictors of late onset cardiotoxicity in asymptomatic survivors of childhood cancer treated with doxorubicin with or without mediastinal irradiation.
Methods.
A cross-sectional study on 58 asymptomatic survivors of childhood cancer who received doxorubicin in their treatment protocols and 32 asymptomatic Hodgkin’s lymphoma survivors who received anthracycline and mediastinal irradiation.
Levels of NT-proBNP, TDI, and conventional echocardiography were determined.
Results.
Thirty percent of survivors had abnormal NT-proBNP levels.
It was significantly related to age at diagnosis, duration of follow-up, and cumulative dose of doxorubicin.
TDI detected myocardial affection in 20% more than conventional echocardiography.
Furthermore, abnormalities in TDI and NT-pro-BNP levels were more common in Hodgkin lymphoma survivors receiving both chemotherapy and radiotherapy.
Conclusions.
TDI could detect early cardiac dysfunction even in those with normal conventional echocardiography.
Measurement of NT-proBNP represents an interesting strategy for detecting subclinical cardiotoxicity.
We recommend prospective and multicenter studies to validate the role of NT-proBNP as an early marker for late onset doxorubicin-induced cardiotoxicity.
American Psychological Association (APA)
Zidan, Amal& Sherief, Laila M.& El-sheikh, Amera& Saleh, Safaa H.& Shahbah, Doaa A.& Kamal, Naglaa M.…[et al.]. 2015. NT-proBNP as Early Marker of Subclinical Late Cardiotoxicity after Doxorubicin Therapy and Mediastinal Irradiation in Childhood Cancer Survivors. Disease Markers،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060964
Modern Language Association (MLA)
Zidan, Amal…[et al.]. NT-proBNP as Early Marker of Subclinical Late Cardiotoxicity after Doxorubicin Therapy and Mediastinal Irradiation in Childhood Cancer Survivors. Disease Markers No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1060964
American Medical Association (AMA)
Zidan, Amal& Sherief, Laila M.& El-sheikh, Amera& Saleh, Safaa H.& Shahbah, Doaa A.& Kamal, Naglaa M.…[et al.]. NT-proBNP as Early Marker of Subclinical Late Cardiotoxicity after Doxorubicin Therapy and Mediastinal Irradiation in Childhood Cancer Survivors. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060964