Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy

المؤلفون المشاركون

Zhang, Huili
Zhu, Yuling
Sun, Yiming
Li, Yaqin
Deng, Langhui
Wen, Xingxuan
Zhang, Cheng
Wang, Huaqiao

المصدر

Disease Markers

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-04-29

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

Differentiation among types of muscular dystrophy (MD) has remained challenging.

In this retrospective study, we sought to develop a methodology for differentiation of MD types using analysis of serum enzyme profiles.

Methods.

The serum levels of enzymes from 232 patients, including 120 with DMD, 36 with BMD, 36 with FSHD, 46 with LGMD, and 11 with EDMD, were evaluated.

Results.

The characteristic profiles of serum enzymes facilitated differentiation of these five types of MD.

DMD was characterized by simultaneous elevation of ALT, AST, LDH, and ALP; BMD and LGMD were characterized by elevation of ALT, AST, and LDH; and FSHD and EDMD were characterized by a lack of abnormal serum enzyme levels.

We further developed discriminant functions to distinguish BMD and LGMD.

For LGMD, LGMD2B patients had significantly higher ALP levels than non-LGMD2B patients ( 98 ± 59 U/L versus 45 ± 9 U/L, resp., p < 0.05 ).

Conclusions.

Our approach enabled the determination of MD subtypes using serum enzyme profiles prior to genetic testing, which will increase the chance a mutation will be found in the first gene analyzed.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhu, Yuling& Zhang, Huili& Sun, Yiming& Li, Yaqin& Deng, Langhui& Wen, Xingxuan…[et al.]. 2015. Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060974

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhu, Yuling…[et al.]. Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060974

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhu, Yuling& Zhang, Huili& Sun, Yiming& Li, Yaqin& Deng, Langhui& Wen, Xingxuan…[et al.]. Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060974

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1060974