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Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy
Joint Authors
Zhang, Huili
Zhu, Yuling
Sun, Yiming
Li, Yaqin
Deng, Langhui
Wen, Xingxuan
Zhang, Cheng
Wang, Huaqiao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Differentiation among types of muscular dystrophy (MD) has remained challenging.
In this retrospective study, we sought to develop a methodology for differentiation of MD types using analysis of serum enzyme profiles.
Methods.
The serum levels of enzymes from 232 patients, including 120 with DMD, 36 with BMD, 36 with FSHD, 46 with LGMD, and 11 with EDMD, were evaluated.
Results.
The characteristic profiles of serum enzymes facilitated differentiation of these five types of MD.
DMD was characterized by simultaneous elevation of ALT, AST, LDH, and ALP; BMD and LGMD were characterized by elevation of ALT, AST, and LDH; and FSHD and EDMD were characterized by a lack of abnormal serum enzyme levels.
We further developed discriminant functions to distinguish BMD and LGMD.
For LGMD, LGMD2B patients had significantly higher ALP levels than non-LGMD2B patients ( 98 ± 59 U/L versus 45 ± 9 U/L, resp., p < 0.05 ).
Conclusions.
Our approach enabled the determination of MD subtypes using serum enzyme profiles prior to genetic testing, which will increase the chance a mutation will be found in the first gene analyzed.
American Psychological Association (APA)
Zhu, Yuling& Zhang, Huili& Sun, Yiming& Li, Yaqin& Deng, Langhui& Wen, Xingxuan…[et al.]. 2015. Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060974
Modern Language Association (MLA)
Zhu, Yuling…[et al.]. Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060974
American Medical Association (AMA)
Zhu, Yuling& Zhang, Huili& Sun, Yiming& Li, Yaqin& Deng, Langhui& Wen, Xingxuan…[et al.]. Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060974