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Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma
المؤلفون المشاركون
Yang, Hang
Jiang, Wen-Qi
Cao, Ye
Sun, Yong-An
Wei, Jing
An, Xin
Zhang, Ying-Chun
Song, Ming
Wang, Shu-Sen
Yuan, Zhong-Yu
Peng, Rou-Jun
Chen, Tan-Huan
Li, Li-Ren
Shi, Yan-Xia
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC).
However, the clinical relevance of this observation in HNSCC is unclear.
The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC.
Methods.
Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study.
Tumor samples from primary sites were collected.
The expression of the ZNF703 protein was tested by immunohistochemistry (IHC).
Results.
The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, P<0.001).
ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P<0.05).
Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P=0.022, hazard ratio = 1.635, 95% CI 1.073–2.493) in HNSCC patients.
Conclusion.
ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Hang& Jiang, Wen-Qi& Cao, Ye& Sun, Yong-An& Wei, Jing& An, Xin…[et al.]. 2015. Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Hang…[et al.]. Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Hang& Jiang, Wen-Qi& Cao, Ye& Sun, Yong-An& Wei, Jing& An, Xin…[et al.]. Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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