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Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma
Joint Authors
Yang, Hang
Jiang, Wen-Qi
Cao, Ye
Sun, Yong-An
Wei, Jing
An, Xin
Zhang, Ying-Chun
Song, Ming
Wang, Shu-Sen
Yuan, Zhong-Yu
Peng, Rou-Jun
Chen, Tan-Huan
Li, Li-Ren
Shi, Yan-Xia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC).
However, the clinical relevance of this observation in HNSCC is unclear.
The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC.
Methods.
Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study.
Tumor samples from primary sites were collected.
The expression of the ZNF703 protein was tested by immunohistochemistry (IHC).
Results.
The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, P<0.001).
ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P<0.05).
Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P=0.022, hazard ratio = 1.635, 95% CI 1.073–2.493) in HNSCC patients.
Conclusion.
ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.
American Psychological Association (APA)
Yang, Hang& Jiang, Wen-Qi& Cao, Ye& Sun, Yong-An& Wei, Jing& An, Xin…[et al.]. 2015. Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060999
Modern Language Association (MLA)
Yang, Hang…[et al.]. Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060999
American Medical Association (AMA)
Yang, Hang& Jiang, Wen-Qi& Cao, Ye& Sun, Yong-An& Wei, Jing& An, Xin…[et al.]. Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060999