High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma
المؤلفون المشاركون
Teng, Weiping
Han, Cheng
Guan, Haixia
Qin, Jing
Yu, Zhenqian
Shi, Liangfeng
Liu, Yongping
Zhao, Na
Li, Yushu
Shan, Zhongyan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear.
Objective.
To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained from patients who underwent thyroid surgery.
Methods.
Data of thyroid nodules obtained from 1,638 patients who underwent thyroid surgery were evaluated.
Thyroid autoimmunity was assessed by the presence of thyroglobulin (TgAb) or thyroid peroxidase antibodies (TPOAb).
Results.
Among our study cohort, the prevalence of elevated TgAb (≥40 IU/mL) and TPOAb (≥50 IU/mL) was higher in patients with DTC than those with benign nodules.
Patients with DTC and elevated TgAb had a higher prevalence of extrathyroidal invasion.
In the multivariate analysis, TgAb ≥ 40 IU/mL was significantly associated with DTC (odds ratio [OR] = 2.10, 95% confidence interval [CI] 1.40–3.15) compared with TgAb < 40 IU/mL group, independent of other confounding factors such as decreased age, single nodule, and elevated TSH level.
In conclusion, elevated TgAb was associated with DTC.
Conclusions.
This study revealed that high levels of TgAb may act as an independent prediction factor for DTC, and suggests that patients with high TgAb concentrations may be predisposed to DTC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qin, Jing& Yu, Zhenqian& Guan, Haixia& Shi, Liangfeng& Liu, Yongping& Zhao, Na…[et al.]. 2015. High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061002
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qin, Jing…[et al.]. High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061002
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qin, Jing& Yu, Zhenqian& Guan, Haixia& Shi, Liangfeng& Liu, Yongping& Zhao, Na…[et al.]. High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061002
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061002
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر