High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma
Joint Authors
Teng, Weiping
Han, Cheng
Guan, Haixia
Qin, Jing
Yu, Zhenqian
Shi, Liangfeng
Liu, Yongping
Zhao, Na
Li, Yushu
Shan, Zhongyan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear.
Objective.
To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained from patients who underwent thyroid surgery.
Methods.
Data of thyroid nodules obtained from 1,638 patients who underwent thyroid surgery were evaluated.
Thyroid autoimmunity was assessed by the presence of thyroglobulin (TgAb) or thyroid peroxidase antibodies (TPOAb).
Results.
Among our study cohort, the prevalence of elevated TgAb (≥40 IU/mL) and TPOAb (≥50 IU/mL) was higher in patients with DTC than those with benign nodules.
Patients with DTC and elevated TgAb had a higher prevalence of extrathyroidal invasion.
In the multivariate analysis, TgAb ≥ 40 IU/mL was significantly associated with DTC (odds ratio [OR] = 2.10, 95% confidence interval [CI] 1.40–3.15) compared with TgAb < 40 IU/mL group, independent of other confounding factors such as decreased age, single nodule, and elevated TSH level.
In conclusion, elevated TgAb was associated with DTC.
Conclusions.
This study revealed that high levels of TgAb may act as an independent prediction factor for DTC, and suggests that patients with high TgAb concentrations may be predisposed to DTC.
American Psychological Association (APA)
Qin, Jing& Yu, Zhenqian& Guan, Haixia& Shi, Liangfeng& Liu, Yongping& Zhao, Na…[et al.]. 2015. High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061002
Modern Language Association (MLA)
Qin, Jing…[et al.]. High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061002
American Medical Association (AMA)
Qin, Jing& Yu, Zhenqian& Guan, Haixia& Shi, Liangfeng& Liu, Yongping& Zhao, Na…[et al.]. High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061002