Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients
المؤلفون المشاركون
Zhang, Wanjiang
Wu, Jiangdong
Lu, Lijun
Zhang, Le
Ding, Yulei
Wu, Fang
Zuo, Weize
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Our study investigated the association between single nucleotide polymorphisms (SNPs) in P2X7 gene and serum immunoglobulin G (IgG) responses to mycobacterium tuberculosis (MTB) in TB patients.
Methods.
A total of 103 TB patients were enrolled as case group and 87 healthy individuals at same geographical region as control group.
The SNP detection of 1513A>C and -762T>C was performed using PCR-RFLP, and the levels of serum IgG responses to MTB in all subjects were determined.
Results.
AC and CC of 1513A>C and TC and CC of -762T>C had higher frequencies in case group than in control group.
TB patients carrying TC and CC of -762T>C had higher positive rate of IgG responses to MTB than those carrying TT.
Additionally, patients carrying TC and CC of -762T>C had more MTB in sputum than those carrying TT.
Conclusion.
P2X7 SNPs, 1513A>C and -762T>C, may be associated with the susceptibility to tuberculosis, and -762T>C SNP may contribute to the development of MTB.
The mutant genotype of -762T>C (TC and CC) may lower human capability of phagocytosis to MTB, leading to an increased morbidity of TB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Jiangdong& Lu, Lijun& Zhang, Le& Ding, Yulei& Wu, Fang& Zuo, Weize…[et al.]. 2015. Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061007
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Jiangdong…[et al.]. Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061007
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Jiangdong& Lu, Lijun& Zhang, Le& Ding, Yulei& Wu, Fang& Zuo, Weize…[et al.]. Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061007
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061007
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر