Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients

Abstract EN

Objective.

Our study investigated the association between single nucleotide polymorphisms (SNPs) in P2X7 gene and serum immunoglobulin G (IgG) responses to mycobacterium tuberculosis (MTB) in TB patients.

Methods.

A total of 103 TB patients were enrolled as case group and 87 healthy individuals at same geographical region as control group.

The SNP detection of 1513A>C and -762T>C was performed using PCR-RFLP, and the levels of serum IgG responses to MTB in all subjects were determined.

Results.

AC and CC of 1513A>C and TC and CC of -762T>C had higher frequencies in case group than in control group.

TB patients carrying TC and CC of -762T>C had higher positive rate of IgG responses to MTB than those carrying TT.

Additionally, patients carrying TC and CC of -762T>C had more MTB in sputum than those carrying TT.

Conclusion.

P2X7 SNPs, 1513A>C and -762T>C, may be associated with the susceptibility to tuberculosis, and -762T>C SNP may contribute to the development of MTB.

The mutant genotype of -762T>C (TC and CC) may lower human capability of phagocytosis to MTB, leading to an increased morbidity of TB.