Assessment of Immunological Biomarkers in the First Year after Heart Transplantation
المؤلفون المشاركون
Mohr, Friedrich-Wilhelm
Dieterlen, Maja-Theresa
Tarnok, Attila
John, Katja
Mende, Meinhard
Barten, Markus J.
Bittner, Hartmuth B.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Pharmacodynamic biomarkers that detect changes of immunological functions have been recognized as a helpful tool to increase the efficacy of immunosuppressive drug therapies.
However, physiological changes of immunological biomarkers following transplantation are not investigated.
Therefore, we assessed frequently used immunological biomarkers of the circulating blood in the first year following heart transplantation (HTx).
Methods.
Activation markers CD25 and CD95, intracellular cytokines IL-2 and IFNγ, chemokines IP10 and MIG, and subsets of dendritic cells as well as antibodies against human leukocyte antigens (HLA) and major histocompatibility complex class I-related chain A (MICA) antigens were analyzed at different time points using flow cytometry and Luminex xMAP technology.
Results.
Expression of IL-2, IFNγ, and plasmacytoid dendritic cells (pDCs) significantly increased p<0.01 during the first year.
Anti-HLA antibodies decreased continuously, while anti-MICA antibodies showed minor increase within the first year.
An association between percentage of pDCs and anti-MICA antibody positivity was proven.
pDCs, IFNγ-producing T cells, and IP10 concentration were associated in a stronger way with age and gender of HTx recipients than with antibodies against HLA or MICA.
Conclusions.
We conclude that certain immunological biomarkers of the circulating blood change during the first year after HTx.
These changes should be considered for interpretation of biomarkers after transplantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dieterlen, Maja-Theresa& John, Katja& Bittner, Hartmuth B.& Mende, Meinhard& Tarnok, Attila& Mohr, Friedrich-Wilhelm…[et al.]. 2015. Assessment of Immunological Biomarkers in the First Year after Heart Transplantation. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061008
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dieterlen, Maja-Theresa…[et al.]. Assessment of Immunological Biomarkers in the First Year after Heart Transplantation. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061008
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dieterlen, Maja-Theresa& John, Katja& Bittner, Hartmuth B.& Mende, Meinhard& Tarnok, Attila& Mohr, Friedrich-Wilhelm…[et al.]. Assessment of Immunological Biomarkers in the First Year after Heart Transplantation. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061008
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061008
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر