Assessment of Immunological Biomarkers in the First Year after Heart Transplantation

Joint Authors

Mohr, Friedrich-Wilhelm
Dieterlen, Maja-Theresa
Tarnok, Attila
John, Katja
Mende, Meinhard
Barten, Markus J.
Bittner, Hartmuth B.

Source

Disease Markers

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-09-30

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Background.

Pharmacodynamic biomarkers that detect changes of immunological functions have been recognized as a helpful tool to increase the efficacy of immunosuppressive drug therapies.

However, physiological changes of immunological biomarkers following transplantation are not investigated.

Therefore, we assessed frequently used immunological biomarkers of the circulating blood in the first year following heart transplantation (HTx).

Methods.

Activation markers CD25 and CD95, intracellular cytokines IL-2 and IFNγ, chemokines IP10 and MIG, and subsets of dendritic cells as well as antibodies against human leukocyte antigens (HLA) and major histocompatibility complex class I-related chain A (MICA) antigens were analyzed at different time points using flow cytometry and Luminex xMAP technology.

Results.

Expression of IL-2, IFNγ, and plasmacytoid dendritic cells (pDCs) significantly increased p<0.01 during the first year.

Anti-HLA antibodies decreased continuously, while anti-MICA antibodies showed minor increase within the first year.

An association between percentage of pDCs and anti-MICA antibody positivity was proven.

pDCs, IFNγ-producing T cells, and IP10 concentration were associated in a stronger way with age and gender of HTx recipients than with antibodies against HLA or MICA.

Conclusions.

We conclude that certain immunological biomarkers of the circulating blood change during the first year after HTx.

These changes should be considered for interpretation of biomarkers after transplantation.

American Psychological Association (APA)

Dieterlen, Maja-Theresa& John, Katja& Bittner, Hartmuth B.& Mende, Meinhard& Tarnok, Attila& Mohr, Friedrich-Wilhelm…[et al.]. 2015. Assessment of Immunological Biomarkers in the First Year after Heart Transplantation. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061008

Modern Language Association (MLA)

Dieterlen, Maja-Theresa…[et al.]. Assessment of Immunological Biomarkers in the First Year after Heart Transplantation. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061008

American Medical Association (AMA)

Dieterlen, Maja-Theresa& John, Katja& Bittner, Hartmuth B.& Mende, Meinhard& Tarnok, Attila& Mohr, Friedrich-Wilhelm…[et al.]. Assessment of Immunological Biomarkers in the First Year after Heart Transplantation. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061008

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1061008