MTHFR C677T Gene Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis Based on 23 Publications
المؤلفون المشاركون
Niu, Yu-Ming
Deng, Mo-Hong
Chen, Wen
Zeng, Xian-Tao
Luo, Jie
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Conflicting results on the association between MTHFR polymorphism and head and neck cancer (HNC) risk were reported.
We therefore performed a meta-analysis to derive a more precise relationship between MTHFR C677T polymorphism and HNC risk.
Methods.
Three online databases of PubMed, Embase, and CNKI were researched on the associations between MTHFR C677T polymorphism and HNC risk.
Twenty-three published case-control studies involving 4,955 cases and 8,805 controls were collected.
Odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the relationship between MTHFR C677T polymorphism and HNC risk.
Sensitivity analysis, cumulative analyses, and publication bias were conducted to validate the strength of the results.
Results.
Overall, no significant association between MTHFR C677T polymorphism and HNC risk was found in this meta-analysis (T versus C: OR = 1.04, 95% CI = 0.92–1.18; TT versus CC: OR = 1.15, 95% CI = 0.90–1.46; CT versus CC: OR = 1.00, 95% CI = 0.85–1.17; CT + TT versus CC: OR = 1.01, 95% CI = 0.87–1.18; TT versus CC + CT: OR = 1.11, 95% CI = 0.98–1.26).
In the subgroup analysis by HWE, ethnicity, study design, cancer location, and negative significant associations were detected in almost all genetic models, except for few significant risks that were found in thyroid cancer.
Conclusion.
This meta-analysis demonstrates that MTHFR C677T polymorphism may not be a risk factor for the developing of HNC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Niu, Yu-Ming& Deng, Mo-Hong& Chen, Wen& Zeng, Xian-Tao& Luo, Jie. 2015. MTHFR C677T Gene Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis Based on 23 Publications. Disease Markers،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061010
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Niu, Yu-Ming…[et al.]. MTHFR C677T Gene Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis Based on 23 Publications. Disease Markers No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061010
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Niu, Yu-Ming& Deng, Mo-Hong& Chen, Wen& Zeng, Xian-Tao& Luo, Jie. MTHFR C677T Gene Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis Based on 23 Publications. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061010
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061010
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر