MTHFR C677T Gene Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis Based on 23 Publications
Joint Authors
Niu, Yu-Ming
Deng, Mo-Hong
Chen, Wen
Zeng, Xian-Tao
Luo, Jie
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Conflicting results on the association between MTHFR polymorphism and head and neck cancer (HNC) risk were reported.
We therefore performed a meta-analysis to derive a more precise relationship between MTHFR C677T polymorphism and HNC risk.
Methods.
Three online databases of PubMed, Embase, and CNKI were researched on the associations between MTHFR C677T polymorphism and HNC risk.
Twenty-three published case-control studies involving 4,955 cases and 8,805 controls were collected.
Odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the relationship between MTHFR C677T polymorphism and HNC risk.
Sensitivity analysis, cumulative analyses, and publication bias were conducted to validate the strength of the results.
Results.
Overall, no significant association between MTHFR C677T polymorphism and HNC risk was found in this meta-analysis (T versus C: OR = 1.04, 95% CI = 0.92–1.18; TT versus CC: OR = 1.15, 95% CI = 0.90–1.46; CT versus CC: OR = 1.00, 95% CI = 0.85–1.17; CT + TT versus CC: OR = 1.01, 95% CI = 0.87–1.18; TT versus CC + CT: OR = 1.11, 95% CI = 0.98–1.26).
In the subgroup analysis by HWE, ethnicity, study design, cancer location, and negative significant associations were detected in almost all genetic models, except for few significant risks that were found in thyroid cancer.
Conclusion.
This meta-analysis demonstrates that MTHFR C677T polymorphism may not be a risk factor for the developing of HNC.
American Psychological Association (APA)
Niu, Yu-Ming& Deng, Mo-Hong& Chen, Wen& Zeng, Xian-Tao& Luo, Jie. 2015. MTHFR C677T Gene Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis Based on 23 Publications. Disease Markers،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061010
Modern Language Association (MLA)
Niu, Yu-Ming…[et al.]. MTHFR C677T Gene Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis Based on 23 Publications. Disease Markers No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061010
American Medical Association (AMA)
Niu, Yu-Ming& Deng, Mo-Hong& Chen, Wen& Zeng, Xian-Tao& Luo, Jie. MTHFR C677T Gene Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis Based on 23 Publications. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061010