OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data
المؤلفون المشاركون
Ali, Kashif
Mahjabeen, Ishrat
Sabir, Maimoona
Mehmood, Humera
Kayani, Mahmood Akhtar
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-19
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
In first part of this study association between OGG1 polymorphisms and breast cancer susceptibility was explored by meta-analysis.
Second part of the study involved 925 subjects, used for mutational analysis of OGG1 gene using PCR-SSCP and sequencing.
Fifteen mutations were observed, which included five intronic mutations, four splice site mutations, two 3′UTR mutations, three missense mutations, and a nonsense mutation.
Significantly (p<0.001) increased (~29 fold) breast cancer risk was associated with a splice site variant g.9800972T>G and 3′UTR variant g.9798848G>A.
Among intronic mutations, highest (~15 fold) increase in breast cancer risk was associated with g.9793680G>A (p<0.009).
Similarly ~14-fold increased risk was associated with Val159Gly (p<0.01), ~17-fold with Gly221Arg (p<0.005), and ~18-fold with Ser326Cys (p<0.004) in breast cancer patients compared with controls, whereas analysis of nonsense mutation showed that ~13-fold (p<0.01) increased breast cancer risk was associated with Trp375STOP in patients compared to controls.
In conclusion, a significant association was observed between OGG1 germ line mutations and breast cancer risk.
These findings provide evidence that OGG1 may prove to be a good candidate of better diagnosis, treatment, and prevention of breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Kashif& Mahjabeen, Ishrat& Sabir, Maimoona& Mehmood, Humera& Kayani, Mahmood Akhtar. 2015. OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data. Disease Markers،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1061014
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Kashif…[et al.]. OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data. Disease Markers No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1061014
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Kashif& Mahjabeen, Ishrat& Sabir, Maimoona& Mehmood, Humera& Kayani, Mahmood Akhtar. OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1061014
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061014
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر