OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data
Joint Authors
Ali, Kashif
Mahjabeen, Ishrat
Sabir, Maimoona
Mehmood, Humera
Kayani, Mahmood Akhtar
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
In first part of this study association between OGG1 polymorphisms and breast cancer susceptibility was explored by meta-analysis.
Second part of the study involved 925 subjects, used for mutational analysis of OGG1 gene using PCR-SSCP and sequencing.
Fifteen mutations were observed, which included five intronic mutations, four splice site mutations, two 3′UTR mutations, three missense mutations, and a nonsense mutation.
Significantly (p<0.001) increased (~29 fold) breast cancer risk was associated with a splice site variant g.9800972T>G and 3′UTR variant g.9798848G>A.
Among intronic mutations, highest (~15 fold) increase in breast cancer risk was associated with g.9793680G>A (p<0.009).
Similarly ~14-fold increased risk was associated with Val159Gly (p<0.01), ~17-fold with Gly221Arg (p<0.005), and ~18-fold with Ser326Cys (p<0.004) in breast cancer patients compared with controls, whereas analysis of nonsense mutation showed that ~13-fold (p<0.01) increased breast cancer risk was associated with Trp375STOP in patients compared to controls.
In conclusion, a significant association was observed between OGG1 germ line mutations and breast cancer risk.
These findings provide evidence that OGG1 may prove to be a good candidate of better diagnosis, treatment, and prevention of breast cancer.
American Psychological Association (APA)
Ali, Kashif& Mahjabeen, Ishrat& Sabir, Maimoona& Mehmood, Humera& Kayani, Mahmood Akhtar. 2015. OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data. Disease Markers،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1061014
Modern Language Association (MLA)
Ali, Kashif…[et al.]. OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data. Disease Markers No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1061014
American Medical Association (AMA)
Ali, Kashif& Mahjabeen, Ishrat& Sabir, Maimoona& Mehmood, Humera& Kayani, Mahmood Akhtar. OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1061014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061014