Serum Cytokine of IL-10 and IL-12 in Chronic Liver Disease: The Immune and Inflammatory Response
المؤلفون المشاركون
El-Emshaty, Hoda Mohamed
Nasif, Wesam Ahmad
Mohamed, Ibrahim Eldsoky
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The current study was designed to investigate the potential association of serum interleukin-10 and interleukin-12 with HCV infection in chronic liver disease and to evaluate their possible role as new biomarkers in HCC development.
Material and Methods.
Forty-one patients suffering from chronic liver disease (33 patients harbor HCV infection and 8 are HCV-negative patients) were enrolled in the present study and histopathologically diagnosed into 15 patients with HCC, 16 patients with LC, and 10 patients with liver histology compatible with precirrhotic hepatitis (PCH).
Ten patients complaining of cholecystitis were included as nondisease control.
Serum levels of IL-10 and IL-12 were measured by enzyme linked immunosorbent assay (ELISA).
Results.
HCV-infected patients showed elevated expression of IL-10 and IL-12 compared to nondisease controls ( P < 0.0001 ) but there is no significant difference with respect to their expression in HCV-negative patients.
Serum IL-10 and IL-12 were elevated significantly with disease progression ( P < 0.0001 ) and a positive correlation coefficient was detected between IL-10, IL-12 ( r = 0.785 , P < 0.0001 ), and transaminase values suggesting their possible role in chronic inflammation progression leading to HCC.
Conclusion.
IL-10 and IL-12 might be involved in chronic inflammation progression leading to HCC and their evaluation could be used as new biomarkers to reflect the degree of inflammation in HCC development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El-Emshaty, Hoda Mohamed& Nasif, Wesam Ahmad& Mohamed, Ibrahim Eldsoky. 2015. Serum Cytokine of IL-10 and IL-12 in Chronic Liver Disease: The Immune and Inflammatory Response. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061017
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El-Emshaty, Hoda Mohamed…[et al.]. Serum Cytokine of IL-10 and IL-12 in Chronic Liver Disease: The Immune and Inflammatory Response. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061017
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El-Emshaty, Hoda Mohamed& Nasif, Wesam Ahmad& Mohamed, Ibrahim Eldsoky. Serum Cytokine of IL-10 and IL-12 in Chronic Liver Disease: The Immune and Inflammatory Response. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061017
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061017
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر