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Serum Cytokine of IL-10 and IL-12 in Chronic Liver Disease: The Immune and Inflammatory Response
Joint Authors
El-Emshaty, Hoda Mohamed
Nasif, Wesam Ahmad
Mohamed, Ibrahim Eldsoky
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The current study was designed to investigate the potential association of serum interleukin-10 and interleukin-12 with HCV infection in chronic liver disease and to evaluate their possible role as new biomarkers in HCC development.
Material and Methods.
Forty-one patients suffering from chronic liver disease (33 patients harbor HCV infection and 8 are HCV-negative patients) were enrolled in the present study and histopathologically diagnosed into 15 patients with HCC, 16 patients with LC, and 10 patients with liver histology compatible with precirrhotic hepatitis (PCH).
Ten patients complaining of cholecystitis were included as nondisease control.
Serum levels of IL-10 and IL-12 were measured by enzyme linked immunosorbent assay (ELISA).
Results.
HCV-infected patients showed elevated expression of IL-10 and IL-12 compared to nondisease controls ( P < 0.0001 ) but there is no significant difference with respect to their expression in HCV-negative patients.
Serum IL-10 and IL-12 were elevated significantly with disease progression ( P < 0.0001 ) and a positive correlation coefficient was detected between IL-10, IL-12 ( r = 0.785 , P < 0.0001 ), and transaminase values suggesting their possible role in chronic inflammation progression leading to HCC.
Conclusion.
IL-10 and IL-12 might be involved in chronic inflammation progression leading to HCC and their evaluation could be used as new biomarkers to reflect the degree of inflammation in HCC development.
American Psychological Association (APA)
El-Emshaty, Hoda Mohamed& Nasif, Wesam Ahmad& Mohamed, Ibrahim Eldsoky. 2015. Serum Cytokine of IL-10 and IL-12 in Chronic Liver Disease: The Immune and Inflammatory Response. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061017
Modern Language Association (MLA)
El-Emshaty, Hoda Mohamed…[et al.]. Serum Cytokine of IL-10 and IL-12 in Chronic Liver Disease: The Immune and Inflammatory Response. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061017
American Medical Association (AMA)
El-Emshaty, Hoda Mohamed& Nasif, Wesam Ahmad& Mohamed, Ibrahim Eldsoky. Serum Cytokine of IL-10 and IL-12 in Chronic Liver Disease: The Immune and Inflammatory Response. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061017