The Impact of Gene Polymorphisms on the Success of Anticholinergic Treatment in Children with Overactive Bladder
المؤلفون المشاركون
Üre, Iyimser
Gürocak, Serhat
Konac, Ece
Senol, Cem
Onen, Ilke Hacer
Menevse, Adnan
Sözen, Sinan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aim.
To determine the impact of gene polymorphisms on detrusor contraction-relaxation harmony in children with lower urinary tract symptoms (LUTS).
Materials and Methods.
Toilet trained children older than 5 years of age with LUTS and normal neurological examination underwent videourodynamic study.
The control group was composed of age matched children with no voiding complaints.
The study group who filled out the voiding dysfunction symptom score before and after the treatment received standard oxybutynin treatment and was reevaluated 1 year after treatment.
Genomic DNA was isolated from all patients and subjected to PCR for amplification.
Genotyping of ARGHEF10, ROCK2, ADRB3, and CYP3A4 was carried out with Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) method.
Results.
34 (45%) and 42 (55%) patients were enrolled in the study and control group, respectively.
ARGEF10 GG, ADRB3 TC, and CYP3A4 AG genotype patients displayed insignificant difference between pre- and posttreatment voiding dysfunction symptom score and bladder volumes.
Conclusions.
The polymorphism of genes in the cholinergic pathway did not significantly differ clinical parameters.
On the other hand, polymorphic patients in the adrenergic pathway seemed to suffer from clinical disappointment.
For this reason, we think that the neglected adrenergic pathway could be a new therapeutic target for the treatment of anticholinergic resistant LUTS in children.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gürocak, Serhat& Konac, Ece& Üre, Iyimser& Senol, Cem& Onen, Ilke Hacer& Sözen, Sinan…[et al.]. 2015. The Impact of Gene Polymorphisms on the Success of Anticholinergic Treatment in Children with Overactive Bladder. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061023
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gürocak, Serhat…[et al.]. The Impact of Gene Polymorphisms on the Success of Anticholinergic Treatment in Children with Overactive Bladder. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061023
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gürocak, Serhat& Konac, Ece& Üre, Iyimser& Senol, Cem& Onen, Ilke Hacer& Sözen, Sinan…[et al.]. The Impact of Gene Polymorphisms on the Success of Anticholinergic Treatment in Children with Overactive Bladder. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061023
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061023
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر