The Impact of Gene Polymorphisms on the Success of Anticholinergic Treatment in Children with Overactive Bladder
Joint Authors
Üre, Iyimser
Gürocak, Serhat
Konac, Ece
Senol, Cem
Onen, Ilke Hacer
Menevse, Adnan
Sözen, Sinan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To determine the impact of gene polymorphisms on detrusor contraction-relaxation harmony in children with lower urinary tract symptoms (LUTS).
Materials and Methods.
Toilet trained children older than 5 years of age with LUTS and normal neurological examination underwent videourodynamic study.
The control group was composed of age matched children with no voiding complaints.
The study group who filled out the voiding dysfunction symptom score before and after the treatment received standard oxybutynin treatment and was reevaluated 1 year after treatment.
Genomic DNA was isolated from all patients and subjected to PCR for amplification.
Genotyping of ARGHEF10, ROCK2, ADRB3, and CYP3A4 was carried out with Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) method.
Results.
34 (45%) and 42 (55%) patients were enrolled in the study and control group, respectively.
ARGEF10 GG, ADRB3 TC, and CYP3A4 AG genotype patients displayed insignificant difference between pre- and posttreatment voiding dysfunction symptom score and bladder volumes.
Conclusions.
The polymorphism of genes in the cholinergic pathway did not significantly differ clinical parameters.
On the other hand, polymorphic patients in the adrenergic pathway seemed to suffer from clinical disappointment.
For this reason, we think that the neglected adrenergic pathway could be a new therapeutic target for the treatment of anticholinergic resistant LUTS in children.
American Psychological Association (APA)
Gürocak, Serhat& Konac, Ece& Üre, Iyimser& Senol, Cem& Onen, Ilke Hacer& Sözen, Sinan…[et al.]. 2015. The Impact of Gene Polymorphisms on the Success of Anticholinergic Treatment in Children with Overactive Bladder. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061023
Modern Language Association (MLA)
Gürocak, Serhat…[et al.]. The Impact of Gene Polymorphisms on the Success of Anticholinergic Treatment in Children with Overactive Bladder. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061023
American Medical Association (AMA)
Gürocak, Serhat& Konac, Ece& Üre, Iyimser& Senol, Cem& Onen, Ilke Hacer& Sözen, Sinan…[et al.]. The Impact of Gene Polymorphisms on the Success of Anticholinergic Treatment in Children with Overactive Bladder. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061023