Association between BMP4 rs17563 Polymorphism and NSCLP Risk: A Meta-Analysis
المؤلفون المشاركون
Niu, Yu-Ming
Deng, Mo-Hong
Hu, Yuan-Yuan
Qin, Chuan-Qi
Long, Xing
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL/P) risk.
Methods.
Four online databases were researched and the related publications were collected.
Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results.
Results.
Six published case-control studies were collected.
Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found.
It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis.
For Chinese population, the BMP4 rs17563 polymorphism was a significantly increased risk for NSCL/P (C versus T: OR = 1.52, 95% CI = 1.28–1.82, P<0.01, I2=0%; CC versus TT: OR = 2.58, 95% CI = 1.74–3.82, P<0.01, I2=0%; TC + CC versus TT: OR = 1.45, 95% CI = 1.14–1.84, P<0.01, I2=0%; CC versus TT + TC: OR=2.46, 95% CI = 1.46–4.14, P<0.01, I2=47.0%).
On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50–0.96, P=0.03, I2=68.5%; TC versus TT: OR = 0.52, 95% CI = 0.40–0.68, P<0.01, I2=0%; TC + CC versus TT: OR = 0.52, 95% CI = 0.35–0.78, P<0.010, I2=54.4%).
Conclusion.
This meta-analysis indicated that BMP4 rs17563 polymorphism could play a different role during the development of NSCL/P based on ethnicity diversity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Yuan-Yuan& Qin, Chuan-Qi& Deng, Mo-Hong& Niu, Yu-Ming& Long, Xing. 2015. Association between BMP4 rs17563 Polymorphism and NSCLP Risk: A Meta-Analysis. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061036
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Yuan-Yuan…[et al.]. Association between BMP4 rs17563 Polymorphism and NSCLP Risk: A Meta-Analysis. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061036
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Yuan-Yuan& Qin, Chuan-Qi& Deng, Mo-Hong& Niu, Yu-Ming& Long, Xing. Association between BMP4 rs17563 Polymorphism and NSCLP Risk: A Meta-Analysis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061036
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061036
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر