Association between BMP4 rs17563 Polymorphism and NSCLP Risk: A Meta-Analysis
Joint Authors
Niu, Yu-Ming
Deng, Mo-Hong
Hu, Yuan-Yuan
Qin, Chuan-Qi
Long, Xing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL/P) risk.
Methods.
Four online databases were researched and the related publications were collected.
Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results.
Results.
Six published case-control studies were collected.
Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found.
It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis.
For Chinese population, the BMP4 rs17563 polymorphism was a significantly increased risk for NSCL/P (C versus T: OR = 1.52, 95% CI = 1.28–1.82, P<0.01, I2=0%; CC versus TT: OR = 2.58, 95% CI = 1.74–3.82, P<0.01, I2=0%; TC + CC versus TT: OR = 1.45, 95% CI = 1.14–1.84, P<0.01, I2=0%; CC versus TT + TC: OR=2.46, 95% CI = 1.46–4.14, P<0.01, I2=47.0%).
On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50–0.96, P=0.03, I2=68.5%; TC versus TT: OR = 0.52, 95% CI = 0.40–0.68, P<0.01, I2=0%; TC + CC versus TT: OR = 0.52, 95% CI = 0.35–0.78, P<0.010, I2=54.4%).
Conclusion.
This meta-analysis indicated that BMP4 rs17563 polymorphism could play a different role during the development of NSCL/P based on ethnicity diversity.
American Psychological Association (APA)
Hu, Yuan-Yuan& Qin, Chuan-Qi& Deng, Mo-Hong& Niu, Yu-Ming& Long, Xing. 2015. Association between BMP4 rs17563 Polymorphism and NSCLP Risk: A Meta-Analysis. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061036
Modern Language Association (MLA)
Hu, Yuan-Yuan…[et al.]. Association between BMP4 rs17563 Polymorphism and NSCLP Risk: A Meta-Analysis. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061036
American Medical Association (AMA)
Hu, Yuan-Yuan& Qin, Chuan-Qi& Deng, Mo-Hong& Niu, Yu-Ming& Long, Xing. Association between BMP4 rs17563 Polymorphism and NSCLP Risk: A Meta-Analysis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061036