CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer
المؤلفون المشاركون
Wettstein, Marian S.
Buser, Lorenz
Hermanns, Thomas
Roudnicky, Filip
Eberli, Daniel
Baumeister, Philipp
Sulser, Tullio
Poyet, Cédric
Wild, Peter J.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
CD73 is a membrane associated 5′-ectonucleotidase that has been proposed as prognostic biomarker in various solid tumors.
The aim of this study is to evaluate CD73 expression in a cohort of patients with primary bladder cancer in regard to its association with clinicopathological features and disease course.
Methods.
Tissue samples from 174 patients with a primary urothelial carcinoma were immunohistochemically assessed on a tissue microarray.
Associations between CD73 expression and retrospectively obtained clinicopathological data were evaluated by contingency analysis.
Survival analysis was performed to investigate the predictive value of CD73 within the subgroup of pTa and pT1 tumors in regard to progression-free survival (PFS).
Results.
High CD73 expression was found in 46 (26.4%) patients and was significantly associated with lower stage, lower grade, less adjacent carcinoma in situ and with lower Ki-67 proliferation index.
High CD73 immunoreactivity in the subgroup of pTa and pT1 tumors (n=158) was significantly associated with longer PFS (HR: 0.228; p=0.047) in univariable Cox regression analysis.
Conclusion.
High CD73 immunoreactivity was associated with favorable clinicopathological features.
Furthermore, it predicts better outcome in the subgroup of pTa and pT1 tumors and may thus serve as additional tool for the selection of patients with favorable prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wettstein, Marian S.& Buser, Lorenz& Hermanns, Thomas& Roudnicky, Filip& Eberli, Daniel& Baumeister, Philipp…[et al.]. 2015. CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061039
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wettstein, Marian S.…[et al.]. CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061039
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wettstein, Marian S.& Buser, Lorenz& Hermanns, Thomas& Roudnicky, Filip& Eberli, Daniel& Baumeister, Philipp…[et al.]. CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061039
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061039
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر