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CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer
Joint Authors
Wettstein, Marian S.
Buser, Lorenz
Hermanns, Thomas
Roudnicky, Filip
Eberli, Daniel
Baumeister, Philipp
Sulser, Tullio
Poyet, Cédric
Wild, Peter J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
CD73 is a membrane associated 5′-ectonucleotidase that has been proposed as prognostic biomarker in various solid tumors.
The aim of this study is to evaluate CD73 expression in a cohort of patients with primary bladder cancer in regard to its association with clinicopathological features and disease course.
Methods.
Tissue samples from 174 patients with a primary urothelial carcinoma were immunohistochemically assessed on a tissue microarray.
Associations between CD73 expression and retrospectively obtained clinicopathological data were evaluated by contingency analysis.
Survival analysis was performed to investigate the predictive value of CD73 within the subgroup of pTa and pT1 tumors in regard to progression-free survival (PFS).
Results.
High CD73 expression was found in 46 (26.4%) patients and was significantly associated with lower stage, lower grade, less adjacent carcinoma in situ and with lower Ki-67 proliferation index.
High CD73 immunoreactivity in the subgroup of pTa and pT1 tumors (n=158) was significantly associated with longer PFS (HR: 0.228; p=0.047) in univariable Cox regression analysis.
Conclusion.
High CD73 immunoreactivity was associated with favorable clinicopathological features.
Furthermore, it predicts better outcome in the subgroup of pTa and pT1 tumors and may thus serve as additional tool for the selection of patients with favorable prognosis.
American Psychological Association (APA)
Wettstein, Marian S.& Buser, Lorenz& Hermanns, Thomas& Roudnicky, Filip& Eberli, Daniel& Baumeister, Philipp…[et al.]. 2015. CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061039
Modern Language Association (MLA)
Wettstein, Marian S.…[et al.]. CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061039
American Medical Association (AMA)
Wettstein, Marian S.& Buser, Lorenz& Hermanns, Thomas& Roudnicky, Filip& Eberli, Daniel& Baumeister, Philipp…[et al.]. CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061039
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061039