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The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage
المؤلفون المشاركون
Jiao, Xiaoyang
He, Ping
Li, Yazhen
Fan, Zhicheng
Si, Mengya
Xie, Qingdong
Chang, Xiaolan
Huang, Dongyang
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Brain injury after intracranial hemorrhage (ICH) results in significant morbidity and mortality.
Blood brain barrier (BBB) disruption is a hallmark of ICH-induced brain injury; however, data mirroring BBB disruption in human ICH are scarce.
The aim of this study was to assess the significance of circulating biomarkers in evaluating BBB disruption after ICH.
Twenty-two patients with ICH were recruited in this study.
Concentrations of the tight junction proteins (TJs) Claudin-5 (CLDN5), Occludin (OCLN), and zonula occludens 1 (ZO-1) and vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) were measured by using enzyme-linked immunosorbent assay in serum and cerebrospinal fluid (CSF) samples obtained from patients with ICH.
The white blood cell (WBC) count in blood and CSF, albumin (ALB) levels in the CSF (ALBCSF), and the BBB ratio were significantly higher in the ICH than in controls (p<0.05).
Significantly higher levels of CLDN5, OCLN, ZO-1, MMP-9, and VEGF in CSF were observed in the ICH group; these biomarkers were also positively associated with BBB ratio (p<0.05).
Our data revealed that circulating TJs could be considered the potential biomarkers reflecting the integrity of the BBB in ICH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiao, Xiaoyang& He, Ping& Li, Yazhen& Fan, Zhicheng& Si, Mengya& Xie, Qingdong…[et al.]. 2015. The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage. Disease Markers،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061064
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiao, Xiaoyang…[et al.]. The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage. Disease Markers No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061064
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiao, Xiaoyang& He, Ping& Li, Yazhen& Fan, Zhicheng& Si, Mengya& Xie, Qingdong…[et al.]. The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061064
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061064
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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