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The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage
Joint Authors
Jiao, Xiaoyang
He, Ping
Li, Yazhen
Fan, Zhicheng
Si, Mengya
Xie, Qingdong
Chang, Xiaolan
Huang, Dongyang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Brain injury after intracranial hemorrhage (ICH) results in significant morbidity and mortality.
Blood brain barrier (BBB) disruption is a hallmark of ICH-induced brain injury; however, data mirroring BBB disruption in human ICH are scarce.
The aim of this study was to assess the significance of circulating biomarkers in evaluating BBB disruption after ICH.
Twenty-two patients with ICH were recruited in this study.
Concentrations of the tight junction proteins (TJs) Claudin-5 (CLDN5), Occludin (OCLN), and zonula occludens 1 (ZO-1) and vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) were measured by using enzyme-linked immunosorbent assay in serum and cerebrospinal fluid (CSF) samples obtained from patients with ICH.
The white blood cell (WBC) count in blood and CSF, albumin (ALB) levels in the CSF (ALBCSF), and the BBB ratio were significantly higher in the ICH than in controls (p<0.05).
Significantly higher levels of CLDN5, OCLN, ZO-1, MMP-9, and VEGF in CSF were observed in the ICH group; these biomarkers were also positively associated with BBB ratio (p<0.05).
Our data revealed that circulating TJs could be considered the potential biomarkers reflecting the integrity of the BBB in ICH.
American Psychological Association (APA)
Jiao, Xiaoyang& He, Ping& Li, Yazhen& Fan, Zhicheng& Si, Mengya& Xie, Qingdong…[et al.]. 2015. The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage. Disease Markers،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061064
Modern Language Association (MLA)
Jiao, Xiaoyang…[et al.]. The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage. Disease Markers No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061064
American Medical Association (AMA)
Jiao, Xiaoyang& He, Ping& Li, Yazhen& Fan, Zhicheng& Si, Mengya& Xie, Qingdong…[et al.]. The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061064