Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release
المؤلفون المشاركون
Lokman, Faradianna E.
Wan Mohamud, Wan Nazaimoon
Östenson, C. G.
Gu, Harvest F.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
To evaluate the antidiabetic effects of Gynostemma pentaphyllum (GP) in Goto-Kakizaki (GK) rat, an animal model of type 2 diabetes, and to investigate the mechanisms of insulin release.
Methods.
Oral glucose tolerance test was performed and plasma insulin levels were measured.
Results.
An oral treatment with GP (0.3 g/kg of body weight daily) for two weeks in GK rats improved glucose tolerance versus placebo group (P<0.01).
Plasma insulin levels were significantly increased in the GP-treated group.
The insulin release from GP-treated GK rats was 1.9-fold higher as compared to the control group (P<0.001).
GP stimulated insulin release in isolated GK rat islets at high glucose.
Opening of ATP-sensitive potassium (K-ATP) channels by diazoxide and inhibition of calcium channels by nifedipine significantly decreased insulin response to GP.
Furthermore, the protein kinase A (PKA) inhibitor H89 decreased the insulin response to GP (P<0.05).
In addition, GP-induced insulin secretion was decreased after preincubation of GK islets with pertussis toxin to inhibit exocytotic Ge proteins (P<0.05).
Conclusion.
The antidiabetic effect of GP is associated with the stimulation of insulin release from the islets.
GP-induced insulin release is partly mediated via K-ATP and L-type Ca2+ channels, the PKA system and also dependent on pertussis toxin sensitive Ge-protein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lokman, Faradianna E.& Gu, Harvest F.& Wan Mohamud, Wan Nazaimoon& Östenson, C. G.. 2015. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061147
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lokman, Faradianna E.…[et al.]. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061147
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lokman, Faradianna E.& Gu, Harvest F.& Wan Mohamud, Wan Nazaimoon& Östenson, C. G.. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061147
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061147
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر