Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release

Joint Authors

Lokman, Faradianna E.
Wan Mohamud, Wan Nazaimoon
Östenson, C. G.
Gu, Harvest F.

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-06-23

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Aims.

To evaluate the antidiabetic effects of Gynostemma pentaphyllum (GP) in Goto-Kakizaki (GK) rat, an animal model of type 2 diabetes, and to investigate the mechanisms of insulin release.

Methods.

Oral glucose tolerance test was performed and plasma insulin levels were measured.

Results.

An oral treatment with GP (0.3 g/kg of body weight daily) for two weeks in GK rats improved glucose tolerance versus placebo group (P<0.01).

Plasma insulin levels were significantly increased in the GP-treated group.

The insulin release from GP-treated GK rats was 1.9-fold higher as compared to the control group (P<0.001).

GP stimulated insulin release in isolated GK rat islets at high glucose.

Opening of ATP-sensitive potassium (K-ATP) channels by diazoxide and inhibition of calcium channels by nifedipine significantly decreased insulin response to GP.

Furthermore, the protein kinase A (PKA) inhibitor H89 decreased the insulin response to GP (P<0.05).

In addition, GP-induced insulin secretion was decreased after preincubation of GK islets with pertussis toxin to inhibit exocytotic Ge proteins (P<0.05).

Conclusion.

The antidiabetic effect of GP is associated with the stimulation of insulin release from the islets.

GP-induced insulin release is partly mediated via K-ATP and L-type Ca2+ channels, the PKA system and also dependent on pertussis toxin sensitive Ge-protein.

American Psychological Association (APA)

Lokman, Faradianna E.& Gu, Harvest F.& Wan Mohamud, Wan Nazaimoon& Östenson, C. G.. 2015. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061147

Modern Language Association (MLA)

Lokman, Faradianna E.…[et al.]. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061147

American Medical Association (AMA)

Lokman, Faradianna E.& Gu, Harvest F.& Wan Mohamud, Wan Nazaimoon& Östenson, C. G.. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061147

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1061147