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Red Palm Oil Attenuates Lead Acetate Induced Testicular Damage in Adult Male Sprague-Dawley Rats
المؤلفون المشاركون
Jegede, A. I.
Offor, U.
Azu, O. O.
Akinloye, O.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
To study the protective effect of Red Palm Oil (RPO) on testicular damage induced by administration of lead acetate on male Sprague-Dawley rats, 28 rats divided into four groups of 7 animals each were used.
They were administered orally with RPO (1 mL and 2 mL) and lead acetate (i.p.) 6 mg/kg body weight/day, respectively.
Treatment was conducted for 8 weeks, and 24 hrs after the last treatment the rats were sacrificed using cervical dislocation.
Sperms collected from epididymis were used for seminal fluid analyses; while the testes sample was used for ROS and oxidative enzyme activities assessment.
Statistical analysis was carried out using GraphPad Prism 5.02 statistical analysis package.
Administration of lead acetate increased generation of reactive oxygen species (ROS) significantly ( p < 0.05 ) as evidenced by the elevated value of H2O2 and LPO and decreased GSH level.
Also there was reduced epididymal sperm count, poor grade of sperm motility, and lower percentage of normal sperm morphology significantly.
Coadministration with RPO, however, has a protective effect against lead toxicity by decreasing H2O2 production, increased GSH level, and increased sperm qualities especially.
This shows that RPO has a potential to attenuate the toxic effect of lead on testicular cells preventing possible resultant male infertility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jegede, A. I.& Offor, U.& Azu, O. O.& Akinloye, O.. 2015. Red Palm Oil Attenuates Lead Acetate Induced Testicular Damage in Adult Male Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061157
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jegede, A. I.…[et al.]. Red Palm Oil Attenuates Lead Acetate Induced Testicular Damage in Adult Male Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061157
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jegede, A. I.& Offor, U.& Azu, O. O.& Akinloye, O.. Red Palm Oil Attenuates Lead Acetate Induced Testicular Damage in Adult Male Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061157
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061157
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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