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Red Palm Oil Attenuates Lead Acetate Induced Testicular Damage in Adult Male Sprague-Dawley Rats
Joint Authors
Jegede, A. I.
Offor, U.
Azu, O. O.
Akinloye, O.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To study the protective effect of Red Palm Oil (RPO) on testicular damage induced by administration of lead acetate on male Sprague-Dawley rats, 28 rats divided into four groups of 7 animals each were used.
They were administered orally with RPO (1 mL and 2 mL) and lead acetate (i.p.) 6 mg/kg body weight/day, respectively.
Treatment was conducted for 8 weeks, and 24 hrs after the last treatment the rats were sacrificed using cervical dislocation.
Sperms collected from epididymis were used for seminal fluid analyses; while the testes sample was used for ROS and oxidative enzyme activities assessment.
Statistical analysis was carried out using GraphPad Prism 5.02 statistical analysis package.
Administration of lead acetate increased generation of reactive oxygen species (ROS) significantly ( p < 0.05 ) as evidenced by the elevated value of H2O2 and LPO and decreased GSH level.
Also there was reduced epididymal sperm count, poor grade of sperm motility, and lower percentage of normal sperm morphology significantly.
Coadministration with RPO, however, has a protective effect against lead toxicity by decreasing H2O2 production, increased GSH level, and increased sperm qualities especially.
This shows that RPO has a potential to attenuate the toxic effect of lead on testicular cells preventing possible resultant male infertility.
American Psychological Association (APA)
Jegede, A. I.& Offor, U.& Azu, O. O.& Akinloye, O.. 2015. Red Palm Oil Attenuates Lead Acetate Induced Testicular Damage in Adult Male Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061157
Modern Language Association (MLA)
Jegede, A. I.…[et al.]. Red Palm Oil Attenuates Lead Acetate Induced Testicular Damage in Adult Male Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061157
American Medical Association (AMA)
Jegede, A. I.& Offor, U.& Azu, O. O.& Akinloye, O.. Red Palm Oil Attenuates Lead Acetate Induced Testicular Damage in Adult Male Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061157