In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major
المؤلفون المشاركون
Ezatpour, Behrouz
Saedi Dezaki, Ebrahim
Mahmoudvand, Hossein
Azadpour, Mojgan
Ezzatkhah, Fatemeh
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The present study aims to evaluate the in vitro and in vivo antileishmanial activities of Pistacia khinjuk Stocks (Anacardiaceae) alcoholic extract and to compare its efficacy with a reference drug, meglumine antimoniate (MA, Glucantime), against Leishmania tropica and Leishmania major.
This extract (0–100 µg/mL) was evaluated in vitro against promastigote and intracellular amastigote forms of L.
tropica (MRHO/IR/75/ER) and then tested on cutaneous leishmaniasis (CL) in male BALB/c mice with L.
major to reproduce the antileishmanial activity topically.
In vitro, P.
khinjuk extract significantly ( P < 0.05 ) inhibited the growth rate of promastigote (IC50 58.6 ± 3.2 µg/mL) and intramacrophage amastigotes ( 37.3 ± 2.5 µg/mL) of L.
tropica as a dose-dependent response.
In the in vivo assay, after 30 days of treatment, 75% recovery was observed in the infected mice treated with 30% extract.
After treatment of the subgroups with the concentration of 20 and 30% of P.
khinjuk extract, mean diameter of lesions was significantly ( P < 0.05 ) reduced.
To conclude, the present investigation demonstrated that P.
vera extract had in vitro and in vivo effectiveness against L.
major.
Obtained findings also provide the scientific evidences that natural plants could be used in the traditional medicine for the prevention and treatment of CL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ezatpour, Behrouz& Saedi Dezaki, Ebrahim& Mahmoudvand, Hossein& Azadpour, Mojgan& Ezzatkhah, Fatemeh. 2015. In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061180
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ezatpour, Behrouz…[et al.]. In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061180
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ezatpour, Behrouz& Saedi Dezaki, Ebrahim& Mahmoudvand, Hossein& Azadpour, Mojgan& Ezzatkhah, Fatemeh. In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061180
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061180
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر