In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major
Joint Authors
Ezatpour, Behrouz
Saedi Dezaki, Ebrahim
Mahmoudvand, Hossein
Azadpour, Mojgan
Ezzatkhah, Fatemeh
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present study aims to evaluate the in vitro and in vivo antileishmanial activities of Pistacia khinjuk Stocks (Anacardiaceae) alcoholic extract and to compare its efficacy with a reference drug, meglumine antimoniate (MA, Glucantime), against Leishmania tropica and Leishmania major.
This extract (0–100 µg/mL) was evaluated in vitro against promastigote and intracellular amastigote forms of L.
tropica (MRHO/IR/75/ER) and then tested on cutaneous leishmaniasis (CL) in male BALB/c mice with L.
major to reproduce the antileishmanial activity topically.
In vitro, P.
khinjuk extract significantly ( P < 0.05 ) inhibited the growth rate of promastigote (IC50 58.6 ± 3.2 µg/mL) and intramacrophage amastigotes ( 37.3 ± 2.5 µg/mL) of L.
tropica as a dose-dependent response.
In the in vivo assay, after 30 days of treatment, 75% recovery was observed in the infected mice treated with 30% extract.
After treatment of the subgroups with the concentration of 20 and 30% of P.
khinjuk extract, mean diameter of lesions was significantly ( P < 0.05 ) reduced.
To conclude, the present investigation demonstrated that P.
vera extract had in vitro and in vivo effectiveness against L.
major.
Obtained findings also provide the scientific evidences that natural plants could be used in the traditional medicine for the prevention and treatment of CL.
American Psychological Association (APA)
Ezatpour, Behrouz& Saedi Dezaki, Ebrahim& Mahmoudvand, Hossein& Azadpour, Mojgan& Ezzatkhah, Fatemeh. 2015. In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061180
Modern Language Association (MLA)
Ezatpour, Behrouz…[et al.]. In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061180
American Medical Association (AMA)
Ezatpour, Behrouz& Saedi Dezaki, Ebrahim& Mahmoudvand, Hossein& Azadpour, Mojgan& Ezzatkhah, Fatemeh. In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061180