Zuogui Jiangtang Jieyu Formulation Prevents Hyperglycaemia and Depressive-Like Behaviour in Rats by Reducing the Glucocorticoid Level in Plasma and Hippocampus
المؤلفون المشاركون
Wang, YuHong
Yang, Hui
Li, Wei
Meng, Pan
Han, YuanShan
Zhang, Xiuli
Cao, DeLiang
Tan, Yuansheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
To determine whether Zuogui Jiangtang Jieyu prescription (ZGJTJY) has hypoglycemic and antidepressant effects which are mediated by corticosterone through adjustment of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and glucocorticoid (GR) levels.
Materials and Methods.
The diabetes-related depression rats were randomly divided into four groups: the model group, metformin (1.8 mg/kg) combined with fluoxetine (10.8 mg/kg) group, and ZGJTJY high and low dose groups.
Four weeks after modeling, blood glucose, behavior, and cognitive function of depression were detected.
The expressions of 11β-HSD1 and GR in hippocampus were measured by western blotting and immunohistochemical experiments.
Results.
We found that (1) the treatment with ZGJTJY (10.26 g/kg) increases the motor activities and improves cognition ability.
(2) ZGJTJY (10.26 g/kg) significantly relieves the disorder in blood and the relative indexes.
(3) ZGJTJY (10.26 g/kg) can reduce hippocampal corticosterone expression levels and further improve hippocampus pathological changes.
(4) ZGJTJY increased the expression of GR accompanied with decreasing 11β-HSD1 in hippocampus.
Conclusions.
ZGJTJY inhibits the expression of 11β-HSD1 and increases GR in hippocampus and subsequently modulates blood glucose levels, and therefore it is potential property that ZGJTJY could be of benefit for the treatment of behavior and cognitive function of diabetes-related depression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, YuHong& Yang, Hui& Li, Wei& Meng, Pan& Han, YuanShan& Zhang, Xiuli…[et al.]. 2015. Zuogui Jiangtang Jieyu Formulation Prevents Hyperglycaemia and Depressive-Like Behaviour in Rats by Reducing the Glucocorticoid Level in Plasma and Hippocampus. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061188
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, YuHong…[et al.]. Zuogui Jiangtang Jieyu Formulation Prevents Hyperglycaemia and Depressive-Like Behaviour in Rats by Reducing the Glucocorticoid Level in Plasma and Hippocampus. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061188
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, YuHong& Yang, Hui& Li, Wei& Meng, Pan& Han, YuanShan& Zhang, Xiuli…[et al.]. Zuogui Jiangtang Jieyu Formulation Prevents Hyperglycaemia and Depressive-Like Behaviour in Rats by Reducing the Glucocorticoid Level in Plasma and Hippocampus. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061188
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061188
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر