Zuogui Jiangtang Jieyu Formulation Prevents Hyperglycaemia and Depressive-Like Behaviour in Rats by Reducing the Glucocorticoid Level in Plasma and Hippocampus
Joint Authors
Wang, YuHong
Yang, Hui
Li, Wei
Meng, Pan
Han, YuanShan
Zhang, Xiuli
Cao, DeLiang
Tan, Yuansheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
To determine whether Zuogui Jiangtang Jieyu prescription (ZGJTJY) has hypoglycemic and antidepressant effects which are mediated by corticosterone through adjustment of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and glucocorticoid (GR) levels.
Materials and Methods.
The diabetes-related depression rats were randomly divided into four groups: the model group, metformin (1.8 mg/kg) combined with fluoxetine (10.8 mg/kg) group, and ZGJTJY high and low dose groups.
Four weeks after modeling, blood glucose, behavior, and cognitive function of depression were detected.
The expressions of 11β-HSD1 and GR in hippocampus were measured by western blotting and immunohistochemical experiments.
Results.
We found that (1) the treatment with ZGJTJY (10.26 g/kg) increases the motor activities and improves cognition ability.
(2) ZGJTJY (10.26 g/kg) significantly relieves the disorder in blood and the relative indexes.
(3) ZGJTJY (10.26 g/kg) can reduce hippocampal corticosterone expression levels and further improve hippocampus pathological changes.
(4) ZGJTJY increased the expression of GR accompanied with decreasing 11β-HSD1 in hippocampus.
Conclusions.
ZGJTJY inhibits the expression of 11β-HSD1 and increases GR in hippocampus and subsequently modulates blood glucose levels, and therefore it is potential property that ZGJTJY could be of benefit for the treatment of behavior and cognitive function of diabetes-related depression.
American Psychological Association (APA)
Wang, YuHong& Yang, Hui& Li, Wei& Meng, Pan& Han, YuanShan& Zhang, Xiuli…[et al.]. 2015. Zuogui Jiangtang Jieyu Formulation Prevents Hyperglycaemia and Depressive-Like Behaviour in Rats by Reducing the Glucocorticoid Level in Plasma and Hippocampus. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061188
Modern Language Association (MLA)
Wang, YuHong…[et al.]. Zuogui Jiangtang Jieyu Formulation Prevents Hyperglycaemia and Depressive-Like Behaviour in Rats by Reducing the Glucocorticoid Level in Plasma and Hippocampus. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061188
American Medical Association (AMA)
Wang, YuHong& Yang, Hui& Li, Wei& Meng, Pan& Han, YuanShan& Zhang, Xiuli…[et al.]. Zuogui Jiangtang Jieyu Formulation Prevents Hyperglycaemia and Depressive-Like Behaviour in Rats by Reducing the Glucocorticoid Level in Plasma and Hippocampus. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061188