Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents
المؤلفون المشاركون
Paniagua-Castro, Norma
Almonte-Flores, Dulce Carolina
Rosales-Castro, Martha
Escalona-Cardoso, Gerardo N.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Evaluation of the phenolic compounds and antioxidant activity of Cedrela odorata L.
and Juglans regia L.
bark extracts was performed in vitro.
Juglans regia showed greater extract concentration and higher antioxidant activity.
Hypoglycemic activity in rats was assessed by generating a glucose tolerance curve and determining the area under the curve (AUC).
Diabetes was later induced by an injection with streptozotocin (65 mg/kg of b.w.) and confirmed after 24 hours.
The extract was administered (200 mg/kg b.w.) over 10 days, and blood glucose was monitored and compared with a control group.
The glucose AUC showed a hypoglycemic effect of J.
regia and C.
odorata in normal rats.
Both extracts reduced hepatic lipid peroxidation in diabetic rats.
Polyphenolic extracts reduced cholesterol levels in a hypercholesterolemic mouse model and decreased hepatic lipid peroxidation.
Polyphenolic extract doses of 100 and 200 mg/kg b.w.
were administered alone or with cyclophosphamide (CPA) 50 mg/kg ip, which was used as a positive control.
Analyses were performed using leukocytes in a comet assay after 4 and 24 h of treatment.
Genotoxic effects were evaluated by the comet assay, which showed that while J.
regia extract had no effect, C.
odorata extract induced slight damage at 200 mg/kg, with the formation of type 0 and 1 comets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Almonte-Flores, Dulce Carolina& Paniagua-Castro, Norma& Escalona-Cardoso, Gerardo N.& Rosales-Castro, Martha. 2015. Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061220
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Almonte-Flores, Dulce Carolina…[et al.]. Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061220
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Almonte-Flores, Dulce Carolina& Paniagua-Castro, Norma& Escalona-Cardoso, Gerardo N.& Rosales-Castro, Martha. Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061220
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061220
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر