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Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents
Joint Authors
Paniagua-Castro, Norma
Almonte-Flores, Dulce Carolina
Rosales-Castro, Martha
Escalona-Cardoso, Gerardo N.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Evaluation of the phenolic compounds and antioxidant activity of Cedrela odorata L.
and Juglans regia L.
bark extracts was performed in vitro.
Juglans regia showed greater extract concentration and higher antioxidant activity.
Hypoglycemic activity in rats was assessed by generating a glucose tolerance curve and determining the area under the curve (AUC).
Diabetes was later induced by an injection with streptozotocin (65 mg/kg of b.w.) and confirmed after 24 hours.
The extract was administered (200 mg/kg b.w.) over 10 days, and blood glucose was monitored and compared with a control group.
The glucose AUC showed a hypoglycemic effect of J.
regia and C.
odorata in normal rats.
Both extracts reduced hepatic lipid peroxidation in diabetic rats.
Polyphenolic extracts reduced cholesterol levels in a hypercholesterolemic mouse model and decreased hepatic lipid peroxidation.
Polyphenolic extract doses of 100 and 200 mg/kg b.w.
were administered alone or with cyclophosphamide (CPA) 50 mg/kg ip, which was used as a positive control.
Analyses were performed using leukocytes in a comet assay after 4 and 24 h of treatment.
Genotoxic effects were evaluated by the comet assay, which showed that while J.
regia extract had no effect, C.
odorata extract induced slight damage at 200 mg/kg, with the formation of type 0 and 1 comets.
American Psychological Association (APA)
Almonte-Flores, Dulce Carolina& Paniagua-Castro, Norma& Escalona-Cardoso, Gerardo N.& Rosales-Castro, Martha. 2015. Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061220
Modern Language Association (MLA)
Almonte-Flores, Dulce Carolina…[et al.]. Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061220
American Medical Association (AMA)
Almonte-Flores, Dulce Carolina& Paniagua-Castro, Norma& Escalona-Cardoso, Gerardo N.& Rosales-Castro, Martha. Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061220