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Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production
المؤلفون المشاركون
Wang, Yue-Hua
Xuan, Zhao-Hong
Tian, Shuo
Du, Guan-Hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons at the substantia nigra.
Mitochondrial dysfunction and inflammatory responses are involved in the mechanism of cell damage in PD.
6-Hydroxydopamine (6-OHDA), a dopamine analog, specifically damages dopaminergic neurons.
Echinacoside (ECH) is a phenylethanoid glycoside isolated from the stems of Cistanche salsa, showing a variety of neuroprotective effects in previous studies.
The present study was to investigate its effect against 6-OHDA-induced neurotoxicity and possible mechanisms in PC12 cells.
The results showed that 6-OHDA reduced cell viability, decreased oxidation-reduction activity, decreased mitochondrial membrane potential, and induced mitochondria-mediated apoptosis compared with untreated PC12 cells.
However, echinacoside treatment significantly attenuated these changes induced by 6-OHDA.
In addition, echinacoside also could significantly alleviate the inflammatory responses induced by 6-OHDA.
Further research showed that echinacoside could reduce 6-OHDA-induced ROS production in PC12 cells.
These results suggest that the underlying mechanism of echinacoside against 6-OHDA-induced neurotoxicity may be involve in attenuating mitochondrial dysfunction and inflammatory responses by reducing ROS production.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yue-Hua& Xuan, Zhao-Hong& Tian, Shuo& Du, Guan-Hua. 2015. Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061222
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yue-Hua…[et al.]. Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061222
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yue-Hua& Xuan, Zhao-Hong& Tian, Shuo& Du, Guan-Hua. Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061222
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061222
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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