Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production
Joint Authors
Wang, Yue-Hua
Xuan, Zhao-Hong
Tian, Shuo
Du, Guan-Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons at the substantia nigra.
Mitochondrial dysfunction and inflammatory responses are involved in the mechanism of cell damage in PD.
6-Hydroxydopamine (6-OHDA), a dopamine analog, specifically damages dopaminergic neurons.
Echinacoside (ECH) is a phenylethanoid glycoside isolated from the stems of Cistanche salsa, showing a variety of neuroprotective effects in previous studies.
The present study was to investigate its effect against 6-OHDA-induced neurotoxicity and possible mechanisms in PC12 cells.
The results showed that 6-OHDA reduced cell viability, decreased oxidation-reduction activity, decreased mitochondrial membrane potential, and induced mitochondria-mediated apoptosis compared with untreated PC12 cells.
However, echinacoside treatment significantly attenuated these changes induced by 6-OHDA.
In addition, echinacoside also could significantly alleviate the inflammatory responses induced by 6-OHDA.
Further research showed that echinacoside could reduce 6-OHDA-induced ROS production in PC12 cells.
These results suggest that the underlying mechanism of echinacoside against 6-OHDA-induced neurotoxicity may be involve in attenuating mitochondrial dysfunction and inflammatory responses by reducing ROS production.
American Psychological Association (APA)
Wang, Yue-Hua& Xuan, Zhao-Hong& Tian, Shuo& Du, Guan-Hua. 2015. Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061222
Modern Language Association (MLA)
Wang, Yue-Hua…[et al.]. Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061222
American Medical Association (AMA)
Wang, Yue-Hua& Xuan, Zhao-Hong& Tian, Shuo& Du, Guan-Hua. Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061222