MicroRNA Profiling Response to Acupuncture Therapy in Spontaneously Hypertensive Rats

المؤلفون المشاركون

Zhou, Shu-Feng
Wang, Jia-You
Li, Hui
Ma, Chun-Mei
Wang, Jia-Lu
Lai, Xin-Sheng

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-03-15

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

MicroRNAs (miRNAs) are a group of endogenous noncoding RNAs that play important roles in many biological processes.

This study aimed to check if miRNAs were involved in the response to acupuncture in rats.

Microarray analysis was performed to compare the miRNA expression profiles of medulla in spontaneously hypertensive rats (SHRs) treated with or without acupuncture.

Our microarray analysis identified 222 differentially expressed miRNAs in the medulla of SHRs treated with acupuncture at taichong acupoint.

Among these miRNAs, 23 miRNAs with a significant difference were found in acupuncture-treated SHRs compared to untreated rats.

These 23 miRNAs could regulate 2963 target genes which were enriched in at least 14 pathways based on our bioinformatic analysis.

miRNA-339, miR-223, and miR-145 were downregulated in the medulla of SHRs compared to normotensive rats.

Notably, these miRNAs were upregulated to basal levels in the medulla of SHRs treated with acupuncture at taichong in comparison with SHRs receiving acupuncture at nonacupoint group or SHRs without any treatment.

Our findings have revealed significant changes of a panel of selective miRNAs in hypertensive rats treated at taichong acupoint.

These data provide insights into how acupuncture elicits beneficial effects on hypertension.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Jia-You& Li, Hui& Ma, Chun-Mei& Wang, Jia-Lu& Lai, Xin-Sheng& Zhou, Shu-Feng. 2015. MicroRNA Profiling Response to Acupuncture Therapy in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061236

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Jia-You…[et al.]. MicroRNA Profiling Response to Acupuncture Therapy in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061236

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Jia-You& Li, Hui& Ma, Chun-Mei& Wang, Jia-Lu& Lai, Xin-Sheng& Zhou, Shu-Feng. MicroRNA Profiling Response to Acupuncture Therapy in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061236

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1061236