MicroRNA Profiling Response to Acupuncture Therapy in Spontaneously Hypertensive Rats
Joint Authors
Zhou, Shu-Feng
Wang, Jia-You
Li, Hui
Ma, Chun-Mei
Wang, Jia-Lu
Lai, Xin-Sheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are a group of endogenous noncoding RNAs that play important roles in many biological processes.
This study aimed to check if miRNAs were involved in the response to acupuncture in rats.
Microarray analysis was performed to compare the miRNA expression profiles of medulla in spontaneously hypertensive rats (SHRs) treated with or without acupuncture.
Our microarray analysis identified 222 differentially expressed miRNAs in the medulla of SHRs treated with acupuncture at taichong acupoint.
Among these miRNAs, 23 miRNAs with a significant difference were found in acupuncture-treated SHRs compared to untreated rats.
These 23 miRNAs could regulate 2963 target genes which were enriched in at least 14 pathways based on our bioinformatic analysis.
miRNA-339, miR-223, and miR-145 were downregulated in the medulla of SHRs compared to normotensive rats.
Notably, these miRNAs were upregulated to basal levels in the medulla of SHRs treated with acupuncture at taichong in comparison with SHRs receiving acupuncture at nonacupoint group or SHRs without any treatment.
Our findings have revealed significant changes of a panel of selective miRNAs in hypertensive rats treated at taichong acupoint.
These data provide insights into how acupuncture elicits beneficial effects on hypertension.
American Psychological Association (APA)
Wang, Jia-You& Li, Hui& Ma, Chun-Mei& Wang, Jia-Lu& Lai, Xin-Sheng& Zhou, Shu-Feng. 2015. MicroRNA Profiling Response to Acupuncture Therapy in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061236
Modern Language Association (MLA)
Wang, Jia-You…[et al.]. MicroRNA Profiling Response to Acupuncture Therapy in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061236
American Medical Association (AMA)
Wang, Jia-You& Li, Hui& Ma, Chun-Mei& Wang, Jia-Lu& Lai, Xin-Sheng& Zhou, Shu-Feng. MicroRNA Profiling Response to Acupuncture Therapy in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061236