MicroRNAs’ Involvement in Osteoarthritis and the Prospects for Treatments
المؤلفون المشاركون
Peng, Jiang
Wang, Ai-Yuan
Meng, Hao-Ye
Yu, Xiao-Ming
Guo, Quan-Yi
Lu, Shi-Bi
Wang, Yu
Yuan, Xue-Ling
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-26
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Osteoarthritis (OA) is a chronic disease and its etiology is complex.
With increasing OA incidence, more and more people are facing heavy financial and social burdens from the disease.
Genetics-related aspects of OA pathogenesis are not well understood.
Recent reports have examined the molecular mechanisms and genes related to OA.
It has been realized that genetic changes in articular cartilage and bone may contribute to OA’s development.
Osteoclasts, osteoblasts, osteocytes, and chondrocytes in joints must express appropriate genes to achieve tissue homeostasis, and errors in this can cause OA.
MicroRNAs (miRNAs) are small noncoding RNAs that have been discovered to be overarching regulators of gene expression.
Their ability to repress many target genes and their target-binding specificity indicate a complex network of interactions, which is still being defined.
Many studies have focused on the role of miRNAs in bone and cartilage and have identified numbers of miRNAs that play important roles in regulating bone and cartilage homeostasis.
Those miRNAs may also be involved in the pathology of OA, which is the focus of this review.
Future studies on the role of miRNAs in OA will provide important clues leading to a better understanding of the mechanism(s) of OA and, more particularly, to the development of therapeutic targets for OA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Xiao-Ming& Meng, Hao-Ye& Yuan, Xue-Ling& Wang, Yu& Guo, Quan-Yi& Peng, Jiang…[et al.]. 2015. MicroRNAs’ Involvement in Osteoarthritis and the Prospects for Treatments. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061264
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Xiao-Ming…[et al.]. MicroRNAs’ Involvement in Osteoarthritis and the Prospects for Treatments. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1061264
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Xiao-Ming& Meng, Hao-Ye& Yuan, Xue-Ling& Wang, Yu& Guo, Quan-Yi& Peng, Jiang…[et al.]. MicroRNAs’ Involvement in Osteoarthritis and the Prospects for Treatments. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061264
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061264
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر